The application of genomics to emerging zoonotic viral diseases.
Identifieur interne : 002998 ( Main/Exploration ); précédent : 002997; suivant : 002999The application of genomics to emerging zoonotic viral diseases.
Auteurs : Bart L. Haagmans [Pays-Bas] ; Arno C. Andeweg ; Albert D M E. OsterhausSource :
- PLoS pathogens [ 1553-7374 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Grippe humaine (transmission), Grippe humaine (virologie), Génomique (tendances), Humains, Infections à Orthomyxoviridae (transmission), Infections à Orthomyxoviridae (virologie), Maladies transmissibles émergentes (transmission), Maladies transmissibles émergentes (virologie), Syndrome respiratoire aigu sévère (transmission), Syndrome respiratoire aigu sévère (virologie), Virus de la grippe A (génétique), Virus du SRAS (génétique), Zoonoses (transmission).
- MESH :
- génétique : Virus de la grippe A, Virus du SRAS.
- tendances : Génomique.
- virologie : Grippe humaine, Infections à Orthomyxoviridae, Maladies transmissibles émergentes, Syndrome respiratoire aigu sévère.
- transmission : Animaux, Grippe humaine, Humains, Infections à Orthomyxoviridae, Maladies transmissibles émergentes, Syndrome respiratoire aigu sévère, Zoonoses.
English descriptors
- KwdEn :
- Animals, Communicable Diseases, Emerging (transmission), Communicable Diseases, Emerging (virology), Genomics (trends), Humans, Influenza A virus (genetics), Influenza, Human (transmission), Influenza, Human (virology), Orthomyxoviridae Infections (transmission), Orthomyxoviridae Infections (virology), SARS Virus (genetics), Severe Acute Respiratory Syndrome (transmission), Severe Acute Respiratory Syndrome (virology), Zoonoses (transmission).
- MESH :
- genetics : Influenza A virus, SARS Virus.
- transmission : Communicable Diseases, Emerging, Influenza, Human, Orthomyxoviridae Infections, Severe Acute Respiratory Syndrome, Zoonoses.
- trends : Genomics.
- virology : Communicable Diseases, Emerging, Influenza, Human, Orthomyxoviridae Infections, Severe Acute Respiratory Syndrome.
- Animals, Humans.
Abstract
Interspecies transmission of pathogens may result in the emergence of new infectious diseases in humans as well as in domestic and wild animals. Genomics tools such as high-throughput sequencing, mRNA expression profiling, and microarray-based analysis of single nucleotide polymorphisms are providing unprecedented ways to analyze the diversity of the genomes of emerging pathogens as well as the molecular basis of the host response to them. By comparing and contrasting the outcomes of an emerging infection with those of closely related pathogens in different but related host species, we can further delineate the various host pathways determining the outcome of zoonotic transmission and adaptation to the newly invaded species. The ultimate challenge is to link pathogen and host genomics data with biological outcomes of zoonotic transmission and to translate the integrated data into novel intervention strategies that eventually will allow the effective control of newly emerging infectious diseases.
DOI: 10.1371/journal.ppat.1000557
PubMed: 19855817
Affiliations:
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Le document en format XML
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<term>Génomique (tendances)</term>
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<term>Infections à Orthomyxoviridae (transmission)</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
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<front><div type="abstract" xml:lang="en">Interspecies transmission of pathogens may result in the emergence of new infectious diseases in humans as well as in domestic and wild animals. Genomics tools such as high-throughput sequencing, mRNA expression profiling, and microarray-based analysis of single nucleotide polymorphisms are providing unprecedented ways to analyze the diversity of the genomes of emerging pathogens as well as the molecular basis of the host response to them. By comparing and contrasting the outcomes of an emerging infection with those of closely related pathogens in different but related host species, we can further delineate the various host pathways determining the outcome of zoonotic transmission and adaptation to the newly invaded species. The ultimate challenge is to link pathogen and host genomics data with biological outcomes of zoonotic transmission and to translate the integrated data into novel intervention strategies that eventually will allow the effective control of newly emerging infectious diseases.</div>
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